Urine Pathogen Panel

PCR Molecular Urine Pathogen Testing. Rapid, Sensitive Capabilities

Urine cultures have high diagnostic error rates. Madison Core Labs’ PCR Urine Pathogen Panel is highly sensitive, accurate, and faster than urine culture testing.

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Why Molecular Urine Testing Is Needed?

  • Traditional urine culture and sensitivity has an error rate of 33%
  • Pre-analytical handling causes organisms to die before being plated
  • Only 5% of all bacteria can grow in culture
  • Takes 2-3 days to get a report of organisms culture negative as the bacterial load expressed in urine is low
  • Complicated infections such as prostatitis in men typically return culture negative as the bacterial load expressed in urine is low.

Urine tract infections (UTIs) are one of the most common infections in the United States and consequently are responsible for significant healthcare expenditure. The infections can affect several parts of the urinary tract and lead to severe health consequences, such as permanent kidney damage if left untreated or failed timely treatment. Bacteria are the most common cause of these infections; other microbes, including fungus, also cause UTIs. Effective treatment of a UTI is reliant upon the early and accurate identification of the pathogens. Laboratory testing is critical for the screening and diagnosis of UTIs. Polymerase chain reaction (PCR) molecular testing is able to deliver accurate results with a rapid turnout time and high sensitivity. Appropriate screening can prevent the spread of disease, and accurate diagnosis enables appropriate treatment and patient management.

Molecular Urine Pathogen Panel Info Sheet

What Can MCL Molecular Urine Testing Do?

  • Molecular identification of urinary pathogens is rapid. Report received within 24 hours of sample receipt into the laboratory
  • Does not rely on the ability of organisms to grow on artificial media.
  • Uses genetic signatures within the organism for identification.
  • Diagnostic sensitivity is superior when using molecular diagnostic solution
  • Provides comprehensive drug resistance panel to identify key genetic elements that impact treatment
  • Able to identify infections even when the bacteria count in urine is low. Ideal for patients with prostatitis.

Competitive Advantage

Rapid turn-around time provides actionable intelligence to providers up to 48 hours before culture results

Pre-analytic handling has no effect on sample integrity and reduces number of false negative reports

Cost-effective solution as compared to other molecular labs that run large costly panels with little clinical evidence

Clinical Indications

  1. Confirm the diagnosis of an infectious disease caused by common urinary tract bacterial infections
  2. Help in the differential diagnosis of a pathogen
  3. Assist in the evaluation of the prognosis of a urinary tract infection
  4. Monitor treatment outcome in a urinary tract infection
  5. Provides simultaneous qualitative detection and identification of the most common urinary bacterial nucleic acids

Bacteria Organisms

  • Enterobacter aerogenes
  • Enterobacter cloacae
  • Enterococcus faecalis
  • Enterococcus faecium
  • Escherichia coli
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Proteus mirabilis
  • Proteus vulgaris
  • Pseudomonas aeruginosa
  • Staphylococcus aureus
  • Streptococcus dysgalactiae

PLUS Organisms

  • Citrobacter freundii
  • Proteus vulgaris
  • Staphylococcus saprophyticus
  • Staphylococcus epidermidis

Fungal Organisms

  • Candida albicans
  • Candida glabrata
  • Candida krusei
  • Candida parapsilosis
  • Candida tropicalis

Antibiotic Resistance

  • aaaC4
  • ACC
  • aphaA6
  • Carbapenem Resistance-VIM
  • (blaVIM-2)
  • ErmB
  • mefA
  • mecA
  • GES
  • Oxa_1
  • Quinolone and Fluoroquinolone
  • Resistance – QNRA (qnra2)
  • Tetracycline (tetM)
  • VanAB (VanA2, VanB)
  • Van C1