Urine Pathogen Array

Molecular Urine Pathogen Detection

PROBLEM

  • Traditional urine culture and sensitivity has an error rate of 33%
  • Pre-analytical handling causes organisms to die before being plated
  • Only 5% of all bacteria can grow in culture
  • Takes 2-3 days to get report of organisms culture negative as the bacterial load expressed in urine is low.
  • Complicated infection such as prostatitis in men typically return culture negative as the bacterial load expressed in urine is low.

SOLUTION

  • Molecular identification of urinary pathogens is rapid. Report received within 24 hours of
    sample receipt into laboratory
  • Does not rely on ability of organism to grow on artificial media. Uses genetic signatures within the organism for identification.
  • Diagnostic sensitivity is superior when using molecular diagnostic solution
  • Provides comprehensive drug resistance panel to identify key genetic elements that impact treatment
  • Able to identify infections even when bacteria count in urine is low. Ideal for patients with prostatitis.

COMPETITIVE ADVANTAGE

  • Rapid turn-around time provides actionable intelligence to providers up to 48 hours before culture results
  • Pre-analytic handling has no effect on sample integrity and reduces number of false negative reports
  • Cost effective solution as compared to other molecular labs that run large costly panels with little clinical evidence.

**Most urinary tract infections are caused by a handful of organisms**

Why Molecular Testing?

Specimens collected at doctor’s offices and shipped to a laboratory are affected by pre-analytic handling. Organisms often die before they are plated and reported as a negative result.
Culture methods are optimized for detection of mono-microbial, gram positive, aerobic organisms. Patients that have suffered recurrent UTIs or who have undergone any urethral procedures (foley catheter, urethroscope) often suffer from poly-microbial infections. Most laboratories cannot work up a polymicrobial urine sample and reject the result.
Many laboratories do not provide clear recommendations for management of urinary tract infections.