Diabetes Predict

A Test for Your Genes

DIABETESpredict is a simple DNA test which evaluates genetic predisposition to type 2 diabetes through analysis of 16 single nucleotide polymorphisms (SNPs). This is the first commercially available genetic test for type 2 diabetes. The test was developed at Harvard/MIT with funding of $140 million (published in Scientific Reports – a Nature Research Journal). DIABETESpredict recommended for high-risk individuals (family history, overweight, higher glucose levels, suffered from gestational diabetes)

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Clinical Indications

Type 2 Diabetes Genetic risk assessment, prevention and management in high risk individuals:

  • Overweight and Obese
    (BMI 25 kg/m2 in adults; BMI >85% percentile in children)
  • Sedentary Lifestyle
  • High blood sugar level (100 mg/dl)
  • Increased glycosylated hemoglobin (A1C 5.7%)
  • Family history of Type 2 Diabetes
  • Family history of Gestational Diabetes Mellitus
  • Type 2 Diabetes patient, as index case for family cascade intervention

Clinical Benefits

Identification of type 2 diabetes high risk individuals, to enable prevention and management of the disease

Extra motivation to implement and adhere to a healthy lifestyle – personalized diets and physical exercise – biochem monitoring and pharmaceutical treatment

Family cascade to enable early intervention

More Convenient for Doctors and Patients

Two copies of risk polymorphisms have been detected in the genes WFS1, SLC30A8, KCNQ1, CDKN2A/B, FTP, and PPARG. These polymorphisms are associated with an increased genetic risk of developing type 2 diabetes. In addition, one copy of other polymorphisms also associated with type 2 diabetes has been detected in the genes: HHEX/IDE, TCF7L2, CDKN2A/B, PPARG.

The risk score is calculated by an algorithm that integrates the genotype of the patient with data on the patient’s ethnicity, weight, height, and family history of diabetes. If the information on family history, weight, or height is not provided by the patient, an algorithm will be applied that does not integrate those factors.

Sixteen genetic variants (polymorphisms) were genotyped using TaqMan® OpenArray® high-precision methodology. These 16 variants are relevant in the development of type 2 diabetes and are associated with an increased genetic risk of the disease.

Diabetes Predict does not diagnose type 2 diabetes. A doctor must diagnose type 2 diabetes. These results must be evaluated along with a complete individual and family medical history as well as other laboratory test results. This test analyses and informs only about certain genetic variants associated with the genetic risk of type 2 diabetes. This genetic test does not exclude that the patient might develop other diseases.

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